| Journal Call no. | R644.H63J573 |
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| Author | Ching, C. K. |
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| Article Title | The combination of omeprazole, amoxycillin, and clarithromycin eradicates Helicobacter pylori in 95% of patients -- 7 days of therapy is as good as 10 days / C.K. Ching, Y.K. Chan and W.C. Ng. |
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| Is Part Of | Hong Kong medical journal ; v.4, no.1, Mar 1998, p.7-10, illus. |
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| Abstract | More than half of the known Helicobacter pylori strains are resistant to metronidazole, according to previous Hong Kong studies. The response rates to treatment regimens that comprise metronidazole as one of the antimicrobial agents have usually been disappointing in cases involving metronidazole-resistant strains. The objective of this open cohort evaluation was to assess the efficacy of an alternative regimen that combines omeprazole with amoxycillin and clarithromycin in Helicobacter pylori-positive ulcer and non-ulcer patients in Hong Kong. Furthermore, the article aimed to investigate if 7 days were as good as 10 days of therapy. It studied 186 Helicobacter pylori-positive subjects; 149 subjects received 7 days of combination therapy and 37 subjects received 10 days. The result showed that the overall Helicobacter pylori eradication efficiency was identical (94.6%) for both treatments. The incidences of adverse effects were very similar (16.8% versus 16.2%) and both treatments were well tolerated. Thus, the article proposes that omeprazole in combination with amoxycillin and clarithromycin should be considered as one of the first-line therapies for patients with Helicobacter pylori infection in Hong Kong. |
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