| Abstract | The article investigates the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma conducted at the university teaching hospital, Hong Kong. Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. Outcome measures include demographic data, cancer T- and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. Two (4 percent) patients had been treated with radiotherapy alone, six (12 percent) had undergone radical resection alone, and 42 (84 percent) had been radically treated by using both modalities. The 5-year overall survival and replapse-free survival rates were 78.4 percent and 63.1 percent, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2 percent and 72.8 percent, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radio-therapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14 percent) locoregional failures without distant metastasis, seven (14 percent) cases of distant metastasis without locoregional failures, and four (8 percent) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2 percent). All regional failures (5/50; 10 percent) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. The N-stage is the main prognostic factor of overall survival, relapse- and metastasis-free recovery, and success of treatment for salivary gland carcinoma. |
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