| Journal Call no. | RC681.A1J68 |
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| Author | Cheng, Xun-min. |
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| Article Title | Changes of angiotensin II receptors during neointima hyperplasia after vascular injury / Xun-min Cheng, Guo-xiang He and Guo-chao Wang. |
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| Is Part Of | Journal of the Hong Kong College of Cardiology ; v.6, no.2, Oct 1998, p.88-93, illus. |
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| Abstract | In an attempt to investigate the changes of angiotensin II receptor in neointima formation after vascular injury, the vascular tissue angiotensin II receptor and its subtypes were measured by the radioligand binding assay in a rat model of balloon injury to the iliac artery. As a result, the angiotensin II receptor was increased significantly at day 3, (P<0.01). The maximal binding capacity of receptor in the injured artery was 3 times as those in the sham-operated at day 14, and recovered at day 28. However, the equilibrium dissociation contant (Kd) of receptor was not significantly different (P>0.05). The angiotensin II receptor in the normal and proliferating iliac artery was exclusively angiotensin type 1 receptor. The results reveal that angiotensin II receptor increases after vascular injury, and suggest that angiotensin II was involved in the generation and development of neointima formation after vascular injury by binding with angiotensin type 1 receptor. |
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